2025-04-20

• Expand the database with 63 newly validated Homology of Medicine and Food (HMF) herbs; add corresponding molecular fingerprints and standardized structural data.

2024-11-15

• Add 120 new molecular structures obtained from high-resolution literature mining; unify stereochemistry descriptions and correct several key structural annotations.

2023-07-30

• Update the HMF herb list with 28 additional items; integrate cross-reference information from the National Administration of TCM.

2022-12-28

• Optimize molecular structure display engine; support multi-format structure downloads (SDF, MOL2). Add 300 curated compound structures.

2022-03-10

• Add herb-compound mapping for 90 HMF herbs; update structure normalization pipeline to reduce duplication and structural conflicts.

2021-08-25

• Add new “Homology of Medicine and Food” category and include 45 herbs with validated molecular constituents; support browsing and structure visualization.

2016-07-30

• Corrected structural errors of multiple molecules.

2014-05-31

• Add medcine Sea Cucumber. Version 2.3

2014-04-30  

• Modify the structure errors of several molecules. Version 2.2.1

2014-03-31

• Fix a critical bug which could lead to a terribly slow querying of herbs. Version 2.2

2014-01-25

• Add four important parameters: FASA-, TPSA, RBN and Half-life;

• Add Browse database page. Screening of all the molecules in TCMSP can now be implemented at the Browse molecules page. Note that since this page contains large datasets, modern browser (ex: Google Chrome, Firefox, Safafi) is recommended for users;

• Add Database download option. TCMSP is made available under the  Open Data Commons Open Database License;

• Add a successful case in TCMSP User Guide to introduce the use of TCMSP. Version 2.1
  

2013-12-20

• Add herb name information at the top of the herb result page;

• Add molecular structure displaying and download option at Molecule Information page. Version 2.0.1

2013-11-30  

• Update TCMSP to Version 2.0;

• New website is available at /tcmsp.php now, Old version http://tcmspnw.com will be maintained until 2014.02.10;

• Add network export option;
  

• Lots of errors of ADME parameters were modified.

  
  

2013-10-30  

• Add some chemical structure displaying to Molecule Information page (testing). Version 1.9

  
  

2013-09-30  

• Add blood-brain-barrier (BBB), H bond Donor and H bond Acceptor parameters. Version 1.8

  
  

2013-06-30  

• Add filter option to search result page;

• Remove the advanced search option as filter option is added. Version 1.7

  
  

2013-05-30  

• Add InChIKey to Molecule Information page;

• Add search by InChIKey option;
  

• Remove duplicates molecules according to InChIKey. Version 1.6

  
  

2013-04-30  

• Add some validated Compound-Target relationships. Version 1.5

  
  

2013-03-30  

• Modify the structure errors of several molecules;

• Molecule Information, Target Information and Disease Information page added. Version 1.4

  
  

2012-12-30  

• Modify some structure errors of several molecules. Version 1.3

  
  

2012-11-30  

• Modify some herb Latin name errors. Version 1.2

  
  

2012-10-30  

• Errors of ADME parameters and structure information are modified. Version 1.1

  
  

2012-09-30  

• Building of the TCMSP database. Version 1.0